Gonadorelin Acetate API manufacturer
Product Code: 4008614 Product Code GMP: H-4005-GMP
Key information
Regulatory documentation
DMF: available
CEP: available
Chemical identifier
CAS Number(s): 33515-09-2 (net), 34973-08-5 (acetate)
Synonyms:
- GnRH (Gonadotropin-Releasing Hormone)
- LHRH (Luteinizing Hormone-Releasing Hormone)
- Luliberin
- Luteinizing Hormone-Releasing Factor
Sequence
Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt
Fields of application
- Ovarian follicular cysts (veterinary medicine)
- Use in reproduction medicine
- Diagnosis of the hypothalamic-pituitary-gonadal axis function
- Cryptorchism
- Synchronization of ovulation (veterinary medicine)
Active substance
Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Molecular Information
Molecular formula:
C55H75N17O13
Relative molecular mass:
1182.31 g/mol
Long-term storage:
-20 ± 5°C
Discover how we use synergies to improve Gonadorelin production
Find more relevant information on Goserelin, Leuprorelin and Triptorelin and our unique synthesis approach, that ensures economies of scale for API manufacturing.
Certificate of suitability (CEP)
Gonadorelin Acetate Ph. Eur.
Certificates granted by the Certification Secretariat of the European Directorate for the Quality of Medicines (EDQM) for our peptide APIs.
Why choose Bachem as your Gonadorelin API manufacturer
Leading Peptide expertise
Decades of peptide manufacturing experience ensure exceptional quality and reliability in every Gonadorelin API batch.
High-yield consistency
Advanced manufacturing technologies deliver robust, reproducible, and high‑yield production with outstanding batch‑to‑batch uniformity.
Secure supply assurance
A resilient supply chain, supported by in‑house starting materials and strong inventory, guarantees uninterrupted product availability.
Regulatory confidence
GMP‑certified processes, comprehensive documentation, and accessible DMFs and CEPs streamline global registration pathways.
Comprehensive impurity control
Specialized impurity management services ensure full transparency and compliance throughout the development and approval process.
Scalable, flexible production
Production capabilities ranging from grams to hundreds of kilos support seamless scale‑up from development to commercial supply.
Driving generic drugs together
Rely on our years of experience in manufacturing Peptide APIs for your next commercial drug venture.
Additional Information on Gonadorelin
What is gonadorelin acetate?
Gonadorelin acetate is a synthetic version of the naturally occurring gonadotropin-releasing hormone (GnRH). It’s a decapeptide (composed of 10 amino acids) that interacts primarily with the pituitary gland. When administered, it stimulates the pituitary’s gonadotrope cells to release two key reproductive hormones:
- Luteinizing hormone (LH)
- Follicle-stimulating hormone (FSH)
Due to its ability to influence reproductive hormone production, it’s used medically to treat various reproductive disorders.
Gonadorelin acetate mechanism of action
Gonadorelin acetate works by binding to GnRH receptors on gonadotrope cells in the anterior pituitary gland. This binding triggers a signaling cascade that leads to the release of stored luteinizing hormone (LH) and follicle-stimulating hormone (FSH), increased synthesis of new LH and FSH, and upregulation of GnRH receptor expression. The released gonadotropins (LH and FSH) then travel through the bloodstream to target reproductive organs.
The drug must be administered in a pulsatile manner to effectively mimic the body’s natural hormone release patterns and achieve optimal therapeutic outcomes. Continuous administration, however, can lead to receptor desensitization and will reduce its effectiveness.
What is gonadorelin acetate used for?
Gonadorelin acetate has several therapeutic applications in reproductive medicine. In women, it is primarily used to treat infertility caused by hypothalamic dysfunction, helping to induce ovulation and support pregnancy outcomes. It can also be valuable in diagnosing reproductive disorders by testing the pituitary gland’s response to GnRH stimulation.
In male patients, gonadorelin acetate is employed to treat hypogonadotropic hypogonadism, a condition where the body doesn’t produce sufficient sex hormones due to pituitary or hypothalamic dysfunction. The medication helps stimulate testosterone production and support normal reproductive function.
In veterinary medicine, particularly in cattle breeding, gonadorelin acetate is used to treat ovarian follicular cysts and to synchronize estrous cycles. It can also help treat delayed ovulation and improve reproductive efficiency in dairy herds.
